Expression data of exosomal miRNAs extracted from plasma [Affymetrix miRNA 4.0]

Tuberculosis (TB) is difficult to diagnose under complex clinical conditions. Exosomal miRNAs have emerged as promising disease biomarkers. We aim to investigate the potential of exosomal miRNAs to assist with TB clinical diagnosis. In the present research, we used the Affymetrix Genechip miRNA 4.0 Array to investgate the profiles of differentially expressed miRNAs (DEMs) in the exosomes of peripheral blood plasma. As a result, exosomal miRNA profiling yielded a total of 102 DEMs (98 with up-expression and 4 with down-expression) between the TB (pulmonary tuberculosis and tuberculosis meningitis) patients and controls. Peripheral blood samples of 11 TB patients and 8 healthy individuals were collected for the for exosomal miRNAs extraction and hybridization on Affymetrix microarrays. In TB group, the most frequent (PTB) and the most lethal (TBM) forms were selected: PTB-1, PTB-2, PTB-3, PTB-4, PTB-5, PTB-6, PTB-7, TBM-1, TBM-2, TBM-3 and TBM-4. Meanwhile, 8 healthy individuals were selected as controls: HC-1, HC-2, HC-3, HC-4, HC-5, HC-6, HC-7 and HC-8.