Domino Oxidative [Pd]-Catalysis: One-Pot Synthesis of Fluorenones Starting from Simple Benzylamines and Iodo Arenes
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https://figshare.com/articles/dataset/Domino_Oxidative_Pd_Catalysis_One_Pot_Synthesis_of_Fluorenones_Starting_from_Simple_Benzylamines_and_Iodo_Arenes/2103172
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资源简介：
A domino
[Pd]-catalysis for the efficient synthesis of fluorenones
is presented. The overall reaction proceeds through the formation
of a five membered Pd(II)-cycle via a highly regioselective ortho C(sp2)-H activation(s) of simple benzylamine
that combines with external iodo arenes to give ortho arylated products. Significantly, the reaction further activates
the C(sp3)-H and C(sp2)-H (intramolecular oxidative
Heck coupling) bonds to give tricyclic imine systems. Then the usual
water workup affords the fused tricyclic ketones (fluorenones). Remarkably,
this one-pot operation enabled the effective construction of two C–C
to three C–C bonds
创建时间：
2016-02-12
