Co(III)-Catalyzed C–H Amidation of Nitrogen-Containing Heterocycles with Dioxazolones under Mild Conditions

A cobalt­(III)-catalyzed C-8 selective C–H amidation of quinoline N-oxide using dioxazolone as an amidating reagent under
mild conditions is disclosed. The reaction proceeds efficiently with
excellent functional group compatibility. The utility of the current
method is demonstrated by gram scale synthesis of C-8 amide quinoline N-oxide and by converting this amidated product into functionalized
quinolines. Furthermore, the developed catalytic method is also applicable
for C-7 amidation of N-pyrimidylindolines and ortho-amidation of benzamides.