Metagenomic analysis of the Nasopharyngeal Microbiomes and Resistomes in Asthma, COVID-19 Infected, and Healthy Individuals

A pilot study analyzed the nasopharyngeal microbiome and resistome in individuals with asthma, COVID-19, and healthy controls. The study found a representative diversity of 7558 bacterial and 87 fungal genera, with different patterns in microbial diversity and structure between individuals with asthma and healthy controls. The nasopharynx resistome contains resistance determinants based on antibiotic efflux and inactivation, with a high proportion of ARGs associated with Pseudomonas species. Healthy individuals showed higher bacterial diversity and ARGs, highlighting Pseudomonadales as the primary contributor to the nasopharyngeal resistome.