The MLL-Menin interaction is a molecular dependency in NUP98-rearranged AML [BioChIP-seq]
收藏NIAID Data Ecosystem2026-05-02 收录
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Using mouse and human models of NUP98-rearrranged leukemia, we demonstrate that inhibition of MLL-Menin impairs leukemogenic gene expression and disrupts chromatin binding of MLL1 and NUP98 fusion proteins at a critical subset of genes that is essential for sustaining the undifferentiated leukemia phenotype. Examination of gene expression changes in mouse leukemia cells treated with the MLL-Menin inhibitor VTP50469
创建时间：
2025-07-30
