Whole Exome and RNA sequencing of synchronous female bilateral breast cancers

Synchronous bilateral breast cancer (sBBC) occurs after both breasts have been affected by the same germline genetics and environmental exposures. For a genome-scale molecular characterization of sBBC, we performed tumor-normal whole exome sequencing (WES) and tumor RNAseq on a cohort of 6 patients with sBBC who were treated with neoadjuvant chemotherapy (NAC), including pre-NAC samples and post-NAC samples when there was residual disease. We also performed tumor-normal WES on a validation cohort of 7 patients with sBBC treated with front-line surgery.EGA study EGAS00001006910