five

Vitamin D treatment of M.tb. infected macrophages

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE52819
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As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). Microarrays were used to measure the changes in gene expression induced by 1,25D treatment of H37Rv-infected THP-1 cells Cells were infected at an MOI of 5 or left uninfected, and treated with 10^-7 M 1,25D for 24 hours
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2018-07-26
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