ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
收藏NIAID Data Ecosystem2026-03-10 收录
官方服务：
资源简介：
Highlights • Loss of p62 in the stroma reprograms metabolism to endure glutamine deprivation • Stromal loss of p62 upregulates ATF4 to sustain asparagine-mediated tumor growth • p62 regulates ATF4 stability through ubiquitin-mediated proteasomal degradation • Fibroblast-selective deletion of p62 activates the ATF4-ASNS axis in vivo
创建时间：
2018-01-24
