Highly Diastereoselective and Enantioselective Formal [4 + 3] Cycloaddition of Donor–Acceptor Cyclobutanes with Nitrones
收藏NIAID Data Ecosystem2026-03-08 收录
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资源简介：
The first highly diastereoselective and enantioselective catalytic formal [4 + 3] cycloaddition of 1,1-cyclobutane diester with nitrone has been developed. Sterically hindered chiral SaBOX/Cu(II) complex promotes the reaction efficiently with a broad substrate scope, producing a range of multifunctionalized optically active 1,2-oxazepanes with excellent stereocontrol (up to >99/1 dr and 97% ee).
创建时间：
2015-06-05
