S1 File - Piece-wise linear models of biological systems—Application, analysis, and comparison with nonlinear models using the example of the p53 regulatory module
BackgroundPlants have evolved various sophisticated mechanisms to respond and adapt to changes of abiotic factors in their natural environment. Light is one of the most important abiotic environmental
Molecular dynamics (MD) and related techniques have been used for computer simulations of biomolecular systems for over 40 years, but only recently due to advances in computer hardware, simulation sof
Almost every biomedical systems analysis requires early decisions regarding the choice of the most suitable representations to be used. De facto the most prevalent choice is a system of ordinary diffe
An approach combining genetic, proteomic, computational, and physiological analysis was used to define a protein network that regulates fat storage in budding yeast (Saccharomyces cerevisiae). A compu
Protein synthesis involves translation initiation, elongation, termination, and ribosome recycling, and each step is controlled intricately by many signaling proteins. Translation initiation can be co
