Sensitivity and specificity for rule-based tests applied to high-affinity peptide-MHC binding scores for vaccine classification.

Abbreviations: P. falciparum = Plasmodium falciparum, C. elegans = Caenorhabditis elegans, T. gondii = Toxoplasma gondii, SN = sensitivity (%) = true positives/(true positives+false negatives), SP = specificity (%) = true negatives/(true negatives+false positives). aProteins ordered on statistical property and test thresholds applied to perform a binary classification. bThreshold derived from a trial-and-error approach, using the mean as a seed threshold, on benchmark proteins to achieve the greatest number of true positives and negatives. Same universal rule (i.e. threshold) is applied to P. falciparum and C. elegans data. cBenchmark Proteins are proteins from published studies with known or expected T-cell responses (source species: T. gondii). Sensitivity and specificity for rule-based tests applied to high-affinity peptide-MHC binding scores for vaccine classification.