Assessment of DNA methylation patterns related to ankylosing spondylitis. Assessment of DNA methylation patterns related to ankylosing spondylitis

The aim of this study was to seek more novel ankylosing spondylitis (AS)-associated DNA methylation. Genome wide DNA methylation profiling was profiled in peripheral blood mononuclear cells (PBMCs) from 24 individuals (AS: health controls (HCs) = 12:12) with high-throughput array. The Illumina Infinium MethylationEPIC Array was used to assess these genome-wide methylation patterns. Overall design: DNA methylation was assessed in PBMCs from 12 health controls and 12 patients with AS. PBMC DNA was extracted, bisulfite converted and genome-wide DNA methylation was interrogated using the HumanMethylationEPIC BeadChip (Illumina).