Characteristics of wild type and Akita diabetic mice.

Data collected at 6 weeks of diabetes (6 weeks group), or at 5, 10, or 35 days following cardiotoxin muscle injury at 8 weeks of diabetes (9–13 weeks group). All measures except for soleus fiber area were found to be significantly altered in the diabetic mice. All muscle mass and fiber area measures presented here are from the uninjured muscle; the cardiotoxin injured contralateral leg muscle data are presented in Figure 1. NEFA, non-esterified fatty acids; PAI-1, plasminogen activator inhibitor-1; TA, tibialis anterior; GPS, gastrocnemius-plantaris-soleus complex; GAS, gastrocnemius; SOL, soleus. * denotes significant difference in Akita compared to matching wild type (WT) value as assessed by t-test (P