EGFR Exon20 insertion mutant NPG bound with Compound 39

EGFR Exon20 insertion mutant NPG bound with Compound 39 Descriptor: 1,2-ETHANEDIOL, 3-[(3-fluoranyl-2-methoxy-phenyl)amino]-2-[3-[2-[(2R)-1-propanoylpyrrolidin-2-yl]ethynyl]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Epidermal growth factor receptor Authors: Hilbert, B.J, Brooijmans, N, Milgram, B.C, Pagliarini, R.A. Deposit date: 2024-06-17 Release date: 2025-01-29 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (1.783 Å) Cite: Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer. J.Med.Chem., 68, 2025