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Domino Reactions for the Synthesis of Anthrapyran-2-ones and the Total Synthesis of the Natural Product (±)-BE-26554A

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Figshare2016-02-18 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Domino_Reactions_for_the_Synthesis_of_Anthrapyran_2_ones_and_the_Total_Synthesis_of_the_Natural_Product_BE_26554A/2375143
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A domino alkyne addition/CO insertion/Nu acylation reaction to a series of novel anthrapyran-2-ones in good to excellent yields is described. In addition, an efficient synthetic sequence involving carbonylation, formation of a β-keto-sulfoxide, and cyclization is presented en route to the antibiotic and antitumor compound (±)-BE-26554A.
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2016-02-18
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