Supplementary material.xlsx

Name: Supplementary material.xlsx
Creator: Chavez Fumagalli, Miguel Angel
Published: 2023-01-12T00:00:00+08:00

Figshare2023-01-12 更新2026-04-08 收录

药物重定位计算模拟

抗利什曼病药物

数据链接：

https://figshare.com/articles/dataset/Supplementary_material_xlsx/21867822/1 数据链接链接失效反馈

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资源简介：

The dataset contains in silico analysis on NPs for the repositioning of structural analogs which have anti-arginase and antileishmanial activities for the development of new therapeutics.

提供机构：

Chavez Fumagalli, Miguel Angel

创建时间：

2023-01-12

Targeting the Trypanothione Reductase of Tissue-Residing Leishmania in Hosts’ Reticuloendothelial System: A Flexible Water-Soluble Ferrocenylquinoline-Based Preclinical Drug Candidate

抗利什曼病药物

二茂铁衍生物

Since inception, the magic bullets developed against leishmaniasis traveled a certain path and then dropped down due to either toxicity or the emergence of resistance. The route of administration is a

NIAID Data Ecosystem70

In vitro drug susceptibility of a panel of recent clinical L . infantum isolates against antileishmanial reference drugs in THP-1, bone-marrow derived macrophages (BMMφ) and mouse peritoneal exudative cells (PEC).

抗利什曼病药物

寄生虫药效评估

Intracellular amastigote drug susceptibility against miltefosine (MIL), paromomycin (PMM), pentavalent antimonials (SbV), trivalent antimonials (SbIII) and amphotericin B (AmB). The presented IC50-val

NIAID Data Ecosystem60

Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasis

抗利什曼病药物

构效关系

In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline–metronidazole hybrid compounds was synthesized and tested against the murine mo

NIAID Data Ecosystem40

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

抗利什曼病药物

高通量筛选抑制剂发现

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanot

NIAID Data Ecosystem70

Zipped folder with data spreadsheets for Leishmania inhibitory concentrations (leishmania_ic50) and nectar and pollen flavonoid concentrations (nectar.pollen.flavonoids).

抗利什曼病药物

植物黄酮类化合物分析

(ZIP)

NIAID Data Ecosystem40