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Malaria and typhoid fever remain major health issues in developing countries like Cameroon, with frequent co-infections. The potential liver damage caused by their respective causative pathogens is overlooked in health management, posing a significant risk of severe liver injury and worsening patient conditions. Accordingly, this study investigated the risk factors associated with liver damage in febrile patients with malaria, typhoid fever, or co-infection at the Obili District Medical Center and Mvog-Betsi Dominican Hospital Center, Yaoundé, Cameroon. Over 8 months, 350 febrile patients were evaluated for their adherence to preventive measures concerning malaria and typhoid fever using a structured questionnaire. Blood samples were analyzed for Plasmodium species and Salmonella antibodies and liver enzyme levels were measured. Liver damage was assessed using the Roussel Uclaf Causality Assessment Method. Risk factors for infections and liver damage were identified using Fisher’s Exact and Chi-Square tests, with significance set at P 2.1; P