The computational reconstruction of ancestral proteins provides information on past biological events and has practical implications for biomedicine and biotechnology. Currently available tools for an
@Parentheses contain references from which the values of the free energies of the proteins have been referred. The values of ΔGHX* of the proteins have been calculated using the OneG program. Free ene
†Zscore is calculated according to methodology described by Dima et al. [58]. ‡Sequence design by Shakhnovich et al. [59] which has been used in other studies [42], [43]. §This sequence was obtained t
Crystallographic and spectroscopic characterization of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability Descriptor: 1,2-ETHANEDIOL, Thioredoxin (TrxA-
