CD137 expression in Foxp3+ regulatory T cells is important for controling the progression of type 1 diabetes

CD137-deficient Foxp3+ regulatory T cells display functional alterations compared to the wildtype counterpart. In this study, we used single-cell RNA sequencing to define the differentiation states of islet-infiltrating Tregs and the impact of CD137 deficiency. This dataset is composed of two mouse strains, NOD.Foxp3-EGFP (wildtype) and NOD.Tnfrsf9-/-.Foxp3-EGFP (CD137 knockout), to determine the effect of CD137 deficiency on regulatory T and CD8 T cells in NOD mouse. Pancreatic islet cells were pooled from 6 mice for each strain and Foxp3+ CD4 T cells (Tregs) and CD8 T cells were isolated for scRNA-seq.