B.uniformisJCM5828 alleviated inflammation by inhibiting the NF-kB and MAPK signaling pathways activation

We found that B.uniformis had significant effects on intestinal microflora and metabolites after colonization, but whether the altered microbes and metabolites could affect the gene expression in the colonic epithelium and thus the organism immunity. To investigate the effect of microbiota and metabolites on the signal transduction of colonic epithelial substances, RNA-seq were performed on colonic epithelial samples.