Model Parameters for Pre-exposure Chemoprophylaxis (PrEP) Implementation

‡Except for the most relevant, the subscripts/superscripts have been omitted from the symbols for clarity. ¶For the analyses reported in this paper, we assumed that infections would be detected in the on-PrEP individuals after an average duration of 6 months, when they would stop PrEP and resume baseline sexual activity. Multivariate sensitivity analyses, where we varied the total persistence of drug-resistant virus in infected individuals (i.e. sum of the periods of persistence on- and off-PrEP) between 1 month to 2 years, showed that the model output was not sensitive to changes in this parameter (data not shown). §HIV-1 disease progression was assumed the same for drug resistant and drug sensitive virus because: i) a temporary predominance of drug-resistant mutants was assumed in the model; and ii) though lower viremia has been observed in the experimental setting [24], [85], [86], it is unknown whether PrEP would attenuate the course of HIV-1 infection. †Inverse of the average duration of PrEP use. For the optimistic scenario we assumed the average duration of PrEP use to be equal to the average duration of sexual activity.