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Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives

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Figshare2016-02-12 更新2026-04-29 收录
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A novel approach to chiral anti-α,β-diamino acid derivatives through tandem orthogonal organocatalysis has been developed. Chiral phosphoric acid catalysts control the chemo-, regio-, and stereoselective addition of hydroxylamines to alkylideneoxazolones, while a phosphine catalyst promotes the isomerization of Z- alkylideneoxazolones to the more reactive E- alkylideneoxazolones.

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2016-02-12
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