Summary of GWAS and replication results.

The discovery stage included 1,514 endometriosis cases and 12,660 population controls, and the replication stage included 505 cases and 1,811 controls.aThe P-values were determined using the Cochrane-Armitage trend test. P-values for the Discovery set reflect PCA adjusted P trend values.bOdds-ratios (OR) and confidence intervals (CI) are calculated using the non-risk allele as the reference.cThe Meta analysis was performed using Cochran-Mantel-Haenzel statistics.dP values of heterogeneties (Phet) across discovery and replication stages calculated using Breslow-Day Test.eCochrane-Armitage trend test P-values based on the combined genotypes from the Discovery and Replication data.Significance threshold is 4.59×10−7, and is determined by 0.05/108,699 where 108,699 is the number of independent SNPs in the panel with r2 less than 0.20.