Enantiocontrolled Synthesis of a Tetracyclic Aminal Corresponding to the Core Subunit of Diazonamide A
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https://figshare.com/articles/dataset/Enantiocontrolled_Synthesis_of_a_Tetracyclic_Aminal_Corresponding_to_the_Core_Subunit_of_Diazonamide_A/2184151
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资源简介：
A chiral
benzylic ether serves as an auxiliary for oxindole carboxylation
(dr 5.2:1.0) that sets C10 configuration in a potential
diazonamide precursor. The chiral substituent allows diastereomer
separation and departs during a subsequent acid-catalyzed ring closure
to form a tetracyclic aminal. With suitable N-protection, crystallization
affords the aminal with 98–99% ee.
创建时间：
2016-02-14
