Differences in Function of Reward Circuitry between Adults with Alcohol Dependence and Healthy Control Adults.

Note: Results are from region-of-interest analyses focusing on the OFC, mPFC, DLPFC, and ventral striatum. Analyses were thresholded at pcorrected<0.05 using AlphaSim. df = 135. The contrast generated from the reward task was win > loss. Cluster size is in voxels. There were no regions for which (1) alcohol dependent adults exhibited greater response than healthy adults or (2) less negative functional connectivity with the accumbens than healthy adults. There were null findings for positive functional connectivity. OFC: orbitofrontal cortex. mPFC: medial prefrontal cortex. DLPFC: dorsolateral prefrontal cortex.