Next-generation sequencing has enabled the genome-wide mapping of human DNA replication origins. However, the results obtained using two independent approaches to map replication origins, namely seque
Next-generation sequencing has enabled the genome-wide mapping of human DNA replication origins. However, the results obtained using two independent approaches to map replication origins, namely seque
Because of the lack of information, regulation of DNA replication initiation in mammals is still poorly understood. In order to identify general rules, we have mapped replication origins along 1% of t
The spatio-temporal program of genome replication across eukaryotes is thought to be driven both by the uneven loading of pre-replication complexes (pre-RCs) across the genome at the onset of S-phase,
Eukaryotic genomes are replicated from many origin sites that are licensed by the loading of inactive double hexamers of the replicative DNA helicase, Mcm2-7. How eukaryotic origin positions are speci
