GSEA of differentially expressed cortical genes in psychiatric disorders and non-psychiatric phenotypes.

GSEA was used to analyse the differentially expressed cortical genes, as gene sets, for enrichment of association signal in three different BP GWASs (a German sample, the Norwegian TOP sample and the British WTCCC BP sample [20], [41], [42]), three SCZ GWASs (the Norwegian TOP sample, the German part of a combined German-Dutch SCZ GWAS and a Danish sample [19], [43], [44]) and six non-psychiatric phenotypes (from WTCCC; CD: Crohn's disease, CHD: coronary heart disease, HT: hypertension, RA: rheumatoid arthritis, T1D: type 1 diabetes and T2D: type 2 diabetes, [42]). The analysis was based on extraction of modified Sidak's minimum P-values [45], as implemented in LDsnpR. FDR q-value<0.1 was set as cut-off value for significant enrichment.
*: One FMCx gene was not represented in the data set.
**: Two FMCx genes were not represented in the data set.