MEMENTO

The Memento cohort is a research project implemented within the framework of the 2008-2012 Alzheimer's plan, with the aim of describing and better understanding the clinical evolution of patients with early signs that may evoke the onset of Alzheimer's or other related diseases. One of the main challenges of Memento is to measure, repeatedly in patients with early signs, a series of biomarkers (MRI of the brain, genetic analyses, molecular PET imaging, CSF extracted by lumbar puncture) and risk factors (lifestyle habits, drug treatments, quality of life) and to monitor the development of their neurocognitive performance in parallel. All of these observations should make it possible to understand which parameters explain why some people become sick and others do not. In the longer term, the knowledge accumulated thanks to the Memento study could make it possible to diagnose those with dementia at an earlier stage and to offer them, where available, treatments which will make it possible to stop or slow down the evolution of the disease.