<i>In vivo</i> pharmacodynamics of bicyclic 4-nitroimidazole analogs studied in mice.
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The mean log lung CFU’s in five independent invivo efficacy studies ranged between 6.07 and 6.66 in untreated infected mice. nd = not determined. ΔMean log lung CFU reduction compared to untreated controls. Each data represents mean value ± SEM from 5 animals. $Mean value from three independent experiments (n = 15). *Significant difference at P<0.05 compared to respective PA-824 doses. nsNo significant difference at P<0.05 compared to respective PA-824 doses.
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2014-08-20
