Mycobacterium tuberculosis variant bovis Raw sequence reads

Mycobacterium bovis infection in cattle persists in Mexico, posing a threat to human health. Control of bovine tuberculosis, through the National Program Against Bovine Tuberculosis, has led to the decrease of disease prevalence in most of the country, except for high dairy production regions. A whole genome sequence (WGS) SNP-based analysis of 321 isolates of M. bovis from dairy and beef cattle, as well as humans, was performed to discriminate strains characterized by spoligotyping. Isolates from nine states designated as “area in control” were included in the study. Twelve main genetic groups (SNP groups) were obtained through phylogenetic and genetic diversity analysis. A clear differentiation of the Baja California isolates was seen as they clustered together exclusively. However, isolates from the central states showed no specific grouping whatsoever. The high genetic diversity seen in our results suggests significant persistence of the disease.