Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation
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RNA viruses are ubiquitous components of the global virosphere, yet relatively little is known about their genetic diversity or the cellular mechanisms by which they exploit the biology of their diverse eukaryotic hosts. A hallmark of (+)ssRNA (positive single-stranded RNA) viruses is the ability to remodel host endomembranes for their own replication. However, the subcellular interplay between RNA viruses and host organelles that harbor gene expression systems, such as mitochondria, is complex and poorly understood. Here we report the discovery of 763 new virus sequences belonging to the family Mitoviridae by metatranscriptomic analysis, the identification of previously uncharacterized mitovirus clades, and a putative new viral class. With this expanded understanding of the diversity of mitovirus and encoded RNA-dependent RNA polymerases (RdRps), we annotate mitovirus-specific protein motifs and identify hallmarks of mitochondrial translation, including mitochondrion-specific codo..., This dataset contains raw data and analyses used to produce figures in the referenced manuscript by Begeman, et al. A detailed description of the methods can be found in the manuscript. Data and analyses on which manuscript figures are based are provided in the following formats: .csv (tabular) .txt (text; code), .tre (phylogenetic trees), .fasta (sequence alignment), .sif (Cytoscape analyses), .eps or .png (image files), .pdb (protein structure), .phy (3D protein structure model). Tables are provided as Excel files., , # Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation
## General Information
### Dataset Overview
For a comprehensive overview and the methodology used to generate and process all the data in this repository please see the corresponding open access publication (see below).
### Corresponding Author Information
```
Name: Samantha C Lewis
ORCID: https://orcid.org/0000-0001-6306-443X
Affiliations:
Department of Molecular and Cell Biology, University of California, Berkeley, CA USA
Innovative Genomics Institute, Berkeley, CA, USA
Helen Wills Neuroscience Institute, Berkeley, CA USA
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA USA
email: samlewis@berkeley.edu
```
### Related Publication
```
Begeman, A., Babaian, A., Lewis, S. C., Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation. mSystems 8:e01002-22.(2023). https://doi.org/10.1128/msyst...,
创建时间：
2025-05-20
