BIOGRID CURATED DATA FOR HRD1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for HRD1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Ubiquitin-protein ligase; functions in ER retention of misfolded proteins; required for ER-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon

由 BioGRID (https://thebiogrid.org) 精心整理的 HRD1（酿酒酵母 S288c）的蛋白质-蛋白质、遗传和化学相互作用数据集；定义：泛素蛋白连接酶；参与错误折叠蛋白在内质网中的滞留；对于错误折叠蛋白的与内质网相关降解（ERAD）过程至关重要；与未折叠蛋白反应（UPR）存在遗传关联；通过与 Hrd3p 的关联进行调控；含有一个 H2 指环结构；可能在靶向持续与并可能阻塞内质网定位的转位酶蛋白中发挥普遍作用。