Chronic cadmium exposure induces differential methylation in mice spermatozoa
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https://www.ncbi.nlm.nih.gov/sra/SRP285132
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资源简介：
We used Reduced Representation Bisulfite Sequencing (RRBS) to comprehensively investigate the impact of chronic, low-dose Cd exposure on mice spermatozoa DNA methylation. Adult male C57BL/J6 mice were provided water with or without cadmium chloride. We purified genomic DNA from sperm samples collected after nine weeks of treatment. We found 1,788 differentially methylated sites present at regulatory regions in sperm of mice exposed to chronic, low-dose of Cd compared to vehicle (control) mice. Our results present a comprehensive analysis of the sperm methylome in response to chronic Cd exposure Overall design: DNA methylation profile of mice spermatozoa was generated using RRBS.
创建时间：
2021-01-27
