Identifying Potential Biomarkers Associated with Sebum Production, Pore Enlargement, and Comedones Using Transcriptomic Approaches Supplementary Material

This file provides supporting information for the manuscript Identifying Potential Biomarkers Associated with Sebum Production, Pore Enlargement, and Comedones Using Transcriptomic Approaches. It contains 2 supplementary figures and 3 supplementary tables: Figure S1 shows the 0–7 grade visual reference scale for facial pore severity, which was adopted as the phenotypic criterion for subject enrollment and group allocation; Figure S2 presents representative clinical photographs of the four studied skin phenotypes (DNEP, ONEP, OEP, OEPC) to demonstrate their baseline characteristics; Table S1 lists the phenotype-correlated key genes screened by canonical correlation analysis for each comparison group; Table S2 summarizes the shared enriched GO terms between differentially expressed genes and phenotype-associated key genes across the three groups; Table S3 details the Spearman correlation coefficients and corresponding p-values for the seven core genes and their matched skin physiological parameters. All materials support the grouping criteria, analytical workflow and core conclusions presented in the main text.