Blood transcriptomics for diagnosis, risk, and treatment monitoring in tuberculosis reveal the evolution and resolution of TB disease: Does one signature capture all?

Characterization of Tuberculosis (TB) progression, diagnosis and treatment response with blood transcriptional RNA-seq analyses. Focus and underlying host immunological response and identification of new signatures for TB early diagnosis and treatment monitoring response. Blood transcriptomics RNA-seq dataset that includes blood RNA samples collected from TB progressors at different time points before they progress to active TB disease and at time of diagnosis before anti-TB treatment (ATT), and also samples from active TB patients from diagnosis before any anti-TB treatmentATT and followed during treatment at regular time points up to one year after treatment initiation.