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An instructive role for IL7RA in the development of human B-cell precursor leukemia

NIAID Data Ecosystem2026-03-13 收录

白血病分子机制

CRISPRi功能基因组学

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA785425 数据链接链接失效反馈

官方服务：

资源简介：

NGS sequencing for gDNA and cDNA of CDKN2A region after CRISPR editing

应用场景：

创建时间：

2021-12-02

白血病分子机制

基因靶向治疗

Targeted molecular therapy has yielded remarkable outcomes in certain cancers, but specific therapeutic targets remain elusive for many others. As a result of two independent RNA interference (RNAi) s

NIAID Data Ecosystem70

BT20_24hr_DMSOvERLOTINIB_RNAseq and WHOLE GENOME CRISPR screen

癌症药物机制研究

CRISPRi功能基因组学

BT20 (TNBC) cells were cultured with either DMSO (v/v%) or Erlotinib (10uM) for 24 hours to observe differential expression changes between conditions. CAS-9 expressing BT20 (TNBC) cells were transduc

NIAID Data Ecosystem50

Genome-wide CRISPR-KO screen result statistics and selected synthetic lethal hits.

CRISPRi功能基因组学

合成致死靶点

Genome-wide CRISPR-KO screen result statistics and selected synthetic lethal hits.

Figshare2024-11-19 更新30

Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

癌症免疫治疗耐药性

CRISPRi功能基因组学

Beta score (sheet1), mapping ratio (sheet2), and essential genes list (sheet3) of CRISPR screens.

Figshare2023-03-01 更新50

Supplementary Table 1 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma