Overview of potential transcription factor binding sites in the genomic regions harboring the analyzed IL12B SNPs rs6887695, rs10045431, rs17860508, and rs3212227.

Binding scores differing more than 5 points between major and minor alleles are depicted in bold. Scores differing more than 10 points are depicted in bold italic. The binding score threshold for each allele was set to 75.0.‡Different consensus sequences for the same transcription factor are caused by the deduction of the sequences from different matrices in the TRANSFAC database [45].*For rs17860508, more than two alleles exist. For the major allele, the score comprises the highest score from all four non-minor alleles (-, G, GC, TTAGA). & = score for the GC allele; # = score for the (-) allele; § = score for the TTAGA allele.UTR = untranslated region;Nucleotide codes: K = G or T, M = A or C, R = A or G, S = C or G, W = A or T, N = A, G, C or T.