Inflammation accelerates BCR-ABL1+ B-ALL development through upregulation of Aid

To investigate the mechanism driving BCR-ABL1+ B-ALL progression involves inflammatory stimulation in murine model. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different bone marrow cells derived from BCR-ABL1+ B-ALL mice with lipopolysaccharide treatment Comparative gene expression profiling analysis of RNA-seq data for bone marrow cells derived from the leukemic mice transplanted with PBS-treated Aid WT BCR-ABL1+ B-ALL cells, the leukemic mice transplanted with LPS-treated Aid WT BCR-ABL1+ B-ALL cells , and the leukemic mice transplanted with LPS-treated Aid KO BCR-ABL1+ B-ALL cells