Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study

Background: LSD  is a hallucinogen with complex neurobiological and behavioral effects.  Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence.  We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive and emotional behavior and the associated underlying neuroanatomy and neurocircuitry.   
Methods: Female and male mice were given vehicle, single, or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivi..., Female and male mice were given vehicle, single or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups., , # Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study

[https://doi.org/10.5061/dryad.9kd51c5s9](https://doi.org/10.5061/dryad.9kd51c5s9)

Methods:

Female and male mice were given vehicle, single or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups.

## Data:

This is Resting state functional connectivity data. The three groups, Vehicle, Single-Dose, and Multi-Dose, consist of a total of 34 scans. Below is a description of the IDs:

* Vehicle - 11 scans, labeled: \"B#_V#m/f\"
* Single-Dose - 12 scans, labeled: \"B#_S...