Keratinocytes derived from patient-specific iPSCs recapitulate the genetic signature of psoriasis disease

Induced pluripotent stem cells (iPSCs) were generated from control (Ctrl) and two psoriasis patients (PsO1 and PsO2) having genetic background of psoriasis. The iPSCs were differentiated into epidermal keratinocytes as described in the article entitled "Keratinocytes derived from patient-specific iPSCs recapitulate the genetic signature of psoriasis disease" by Gowher et al. The dataset represent RNA-seq data generated from keratiocytes derived from ctrl-iPSCs and psoriasis patients iPSCs (PsO1 and PsO2). The file name is : Sample name with replicate_overall sample number_read direction_001 where: - Ctrl Rep1 and Ctrl Rep2: Keratinocytes derived from control (Ctrl-iPSCs). - PSO1 Rep1 and PSO1 Rep2: Keratinocytes derived from psoriasis patient iPSCs (PSO1-iPSCs) - PSO2 Rep1 and PSO2 Rep2: Keratinocytes derived from psoriasis patient iPSCs (PSO2-iPSCs). - RNA-seq data was generated from two biological repliicates (Rep1 and Rep2). - Read direction: R1 (Forward), R2 (Reverse).