Epigenetic modifiers are promising targets to improve therapies in patients with cancer. Targeting the methyltransferase DOT1L with small molecule inhibitors has shown promising effects on the control

NIAID Data Ecosystem40

Mouse ILC2 cells from wild-type or Gfi1-KO animals. Mus musculus

细胞免疫学

基因调控机制

Innate type-2 lymphocytes (ILC2s) are a newly described cell type whose biology and contribution to disease are poorly understood. We are interested in investigating the role of the transcription fact

NIAID Data Ecosystem20

Loss of TET2 results in DNA methylation changes in mouse GC B-cells (Bisulfite-Seq data set). Loss of TET2 results in DNA methylation changes in mouse GC B-cells (Bisulfite-Seq data set)

表观遗传学DNA甲基化

细胞免疫学

Absence of Tet2 at mouse cells results in gain of DNA methylation Overall design: Enhanced reduced representation bisulfite sequencing (ERRBS) of mouse TET2 WT and KO GC B-cells

NIAID Data Ecosystem50

TFDP1 activates SPC25-mediated glutamine metabolism to repress anti-tumor immunity of NK cells in lung adenocarcinoma

癌细胞研究

细胞免疫学

The main purpose of this study is to investigate the specific role of SPC25 in the anti-tumor immune process of Natural killer (NK) cells in lung adenocarcinoma (LUAD). The differentially expressed ge

DataCite Commons2025-12-26 更新40

Retinal pigment epithelial cells suppress interleukin-17-producing T-helper 17 cells

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