Synthesis of Spiro[indazole-3,3′-indolin]-2′-ones via [3 + 2] Dipolar Cycloaddition of Arynes with 3‑Diazoindolin-2-ones and Indazolo[2,3‑c]quinazolin-6(5H)‑ones by Subsequent Thermal Isomerization
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An efficient protocol for facile construction of spiro[indazole-3,3′-indolin]-2′-ones was developed via [3 + 2] dipolar cycloaddition of arynes with 3-diazoindolin-2-ones under mild conditions in excellent yields. Subsequent thermal isomerization of the spiro[indazole-3,3′-indolin]-2′-ones readily afforded indazolo[2,3-c]quinazolin-6(5H)-ones.
创建时间：
2017-07-19
