Goodwin1965_EnzymeControlProcess

This a model from the article:
Oscillatory behavior in enzymatic control processes.

Goodwin BC. Adv Enzyme Regul
1965;3:425-38 5861813
,
Abstract:

The demonstration of negative feedback control processes operating at the molecular level in cells is one of the most significant developments in modern biology. The phenomena of feedback inhibition and feedback repression, whereby enzymatic activities are controlled at the level of the enzyme and the gene, respectively, provide a firm experimental basis for the construction of dynamic models which represent the fundamental regulatory activity of cells. The behavior of these and other molecular control circuits thus constitutes the basis of cell physiology, and in effect provides the physiologist with his elementary units of function. The purpose of this paper is to illustrate the type of periodic behavior which can arise in model systems incorporating the essential control features of enzymatic regulatory processes, and to discuss the significance of oscillatory motion in relation to the organization of cellular processes in time.
This model was taken from the CellML repository
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The original model was:
Goodwin BC. (1965) - version02

The original CellML model was created by:
Lloyd, Catherine, May

[e-mail]
The University of Auckland
The Bioengineering Institute
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