at-retinyl is hydrolysed from p-MII:SAG to release atRAL

Eventually the Schiff base linkage between the all-trans-retinyl (at-retinyl) group and opsin is hydrolyzed, releasing all-trans-retinal (atRAL). atRAL repositions to an "exit" site within opsin and is reduced to all-trans-retinol (atROL) by retinol dehydrogenases RDH8 and RDH12 using NADPH as cofactor (see section on rod retinoid cycle), whereupon it exits the rod (Baumann & Bender 1973).

最终，全反式视黄醇（at-retinyl）基团与视蛋白之间的席夫碱连接发生水解，释放出全反式视黄醛（atRAL）。atRAL重新定位至视蛋白内的“出口”位点，并由视黄醇脱氢酶RDH8和RDH12通过辅因子NADPH将其还原为全反式视黄醇（atROL），此后它从视杆细胞中逸出（参见关于视杆细胞视黄酸循环的章节），此过程由Baumann和Bender于1973年所描述。