Transcriptome profiling of murine cardiomyocytes after treatment with recombinant murine Leukemia inhibitory factor (mLIF), murine Oncostatin M (mOSM) and human-like Oncostatin M orthologue (hlOSM).

This study comparatively assesses downstream effects of exclusive activation of Leukemia inhibitory factor receptor (LIFR), Oncostatin M receptor (OSMR) and dual LIFR/OSMR signaling in murine, cultured cardiomyocytes upon administration of recombinant mLIF, mOSM and hlOSM that is capable to activate both receptors in murine cells. Cultures of murine, primary cardiomyocytes were treated with recombinant mLIF, mOSM and hlOSM for 24 hours under normoxic conditions. Addition of equivaltne volumes of steriles PBS (=solvent of proteins) was used as reference/control.