MiRNAs expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression

Recent studies have revealed that microRNAs (miRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the post-transcriptional level. MiRNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and miRNAs in nasopharyngeal carcinoma (NPC) remain unclear. The aim of this study was to investigate the regulatory roles of the TP53 gene in regulating miRNA expression profiles in NPC cell line HNE2. p53 induced miRNAs expression in human nasopharyngeal carcinoma cell line HNE2 was measured at 0, 12, 24 and 48 hours after transfected by pCMV-p53 plasmid.