Homo sapiens Transcriptome or Gene expression

Our results indicated that 8 gene modules were found among these three groups and the gene module which highly related to eutopic endometrial cells was mainly enriched in cell adhesion, embryo implantation and similar, while gene module related to ectopic endometrial cells was mainly enriched in cell migration and so on. The results of differential expression analysis were generally consistent with the WGCNA results through identified significant DEGs between different groups. These DEGs may play an important role in the occurrence of endometriosis, including the progestogen associated gene PAEP, cell adhesion gene POSTN, inflammatory response gene GNLY, the tumor suppressor genes EGR1 and so on. Further analysis suggesting the function of adhesion is stronger in ectopic endometrial cells than in eutopic endometrial cells, while the ectopic endometrium may have a higher potential risk of malignant transformation than eutopic endometrium. Overall, our data provides a reference for understanding the pathogenesis of endometriosis and its relationship with tumors.