Deregulation of ER-Mitochondria Contact Formation and Mitochondrial Calcium Homeostasis Mediated by VDAC in Fragile X Syndrome
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Additional file 4: of RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome
CNS cell type-specific genes from Zhang et al.’s study compared to the Sharma et al. study. Significant DE genes (DEG) identified as cell type-specific from the Zhang et al. study [69] were compared t
Figshare2017-10-25 更新70
The role of mitochondrial calcium in embryonal rhabdomyosarcoma. The role of mitochondrial calcium in embryonal rhabdomyosarcoma
Rhabdomyosarcoma (RMS), the most common paediatric soft-tissue sarcoma, is characterized by cells of skeletal muscle origin that fail to both irreversibly exit the cell cycle and complete skeletal mus
NIAID Data Ecosystem60
Data supporting the GSEA analysis.
The mitochondrial Ca2+ uniporter (MCU) plays crucial role in intramitochondrial Ca2+ uptake, allowing Ca2+-dependent activation of oxidative metabolism. In recent decades, the role of MCU pore-forming
Figshare2024-10-28 更新20
Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex. Tsai et al.
Unprocessed raw Western-blot or BN-PAGE images used in the figures in Tsai et al., PNAS, 2023.
NIAID Data Ecosystem60
MeCP2 Represses the Activity of Topoisomerase IIb in Long Neuronal Genes [ChIP-Seq]
A unique signature of neuronal transcriptomes is the high expression of the longest genes in the genome (e.g. >100 kilobases). These genes encode proteins with essential functions in neuronal physiolo
NIAID Data Ecosystem20
