Characteristics and Inflammatory Markers in Children with Eosinophilic Esophagitis (EoE)

The overall protocol for the samples used in this study collects medical information, blood, and biopsy samples from children with eosinophilic esophagitis (EoE) over time to understand clinical characteristics and disease pathogenesis. Our patient population has confirmed EoE and symptoms of esophageal dysfunction characteristic endoscopic findings of EoE. Fibroblasts isolated from esophageal tissue samples from 2 subjects with active EoE and 2 control subjects were evaluated using single cell RNA-sequencing (scRNA-seq). ]]>
Inclusion Criteria: Age 1 to 65 years, inclusive during routine clinical care who: Have a known EoE diagnosis Dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications) Present with food impaction Present with esophageal stricture Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings ]]>
Not applicable ]]>