Metadata record for the article: High Prevalence of APOA1/C3/A4/A5 Alterations in Luminal Breast Cancers among Young Women in East Asia

<b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related article: “High Prevalence of APOA1/C3/A4/A5 Alterations in Luminal Breast Cancers among Young Women in East Asia”. The related study aimed to identify unique genetic alterations in emerging tumours distinctly characterised by a high prevalence of estrogen receptor (ER)–positive/human epidermal growth factor receptor (HER2)–negative cancer, for which the incidence rate among women aged &lt;50 years in East Asia has rapidly increased. Type of data: copy number variations (CNVs); clinical data Subject of data: <i>Homo sapiens</i> Patient characteristics &amp; recruitment: patients with breast cancer diagnosed between April 2009 and July 2011 at National Taiwan University Hospital (NTUH), Taiwan. The clinicopathological information of these patients was obtained from electronic medical record. <b>Data access</b> The CNV dataset of the 120 breast tumours in the NTUH discovery cohort has been deposited in the <i>Gene Expression Omnibus </i>(GEO)<i> </i>under accession https://identifiers.org/geo:GSE80526. The Metabric dataset is available in the <i>European Nucleotide Archive </i>under accession https://identifiers.org/ena.embl:EGAD00010000164. The breast cancer gene expression datasets used for comparison between East Asian and Western women are available in GEO under accessions: https://identifiers.org/geo:GSE20685, https://identifiers.org/geo:GSE21653, https://identifiers.org/geo:GSE23720, https://identifiers.org/geo:GSE20194, https://identifiers.org/geo:GSE45255. Clinical data in the files ‘NTUH discovery cohort patient data.xlsx’ and ‘NTUH validation cohort patient data.xlsx’ are not publicly available as they contain information that could compromise research participant privacy and informed consent to share participant-level data was not obtained prior to or during data collection. Requests for these data should be directed to Dr. Lin CH with data requests. The file ‘TagMan Copy Number Assay data.xlsx’ is openly available with this data record. <b>Corresponding author(s) for this study</b> Chiun-Sheng Huang, National Taiwan University Hospital, No 7, Chung-Shan South Rd, Taipei 10016, Taiwan. Phone: [phone] ext. 65080; Fax: [phone]; Email: [e-mail]. Ching-Hung Lin, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. [e-mail].<br> <br> <b></b> <b>Study approval </b> The study’s protocol was approved by the ethics committee of NTUH (200902014R).